The hosts, already assured of a sixth-place finish, were looking to gain momentum ahead of their UEFA Conference League final against Chelsea next week. Manuel Pellegrini's side had a difficult time creating clear-cut chances, but managed to break the deadlock with 40 minutes on the clock.
Antony scored the opening goal with a perfectly placed left-footed shot from just inside the penalty area. He received the ball from Isco and kept his cool to find the bottom corner.
Valencia, who still had a slim chance of a top-half finish, responded with a stunning save from Giorgi Mamardashvili, who denied Abde Ezzalzouli's shot from the top corner.
Valencia then equalized with 15 minutes remaining, with Rafa Mir scoring his first LaLiga goal for the club. He drilled his first-time strike into the bottom corner after a pass from Andre Almeida.
Despite pushing for a winner in the closing stages, Valencia ultimately had to settle for a draw. The result means Betis ended the season without a win in three matches, while Valencia's chances of a top-half finish were kept alive.
Betis will now focus on their Conference League final against Chelsea, while Valencia will look to build momentum for next season.
Flashscore Man of the Match: Antony (Real Betis)